InterPro domain: IPR027075
General Information
- Identifier IPR027075
- Description Cleavage and polyadenylation specificity factor subunit 2
- Number of genes 163
- Gene duplication stats Loading...
- Associated GO terms GO:0005847 GO:0006378 GO:0006379
Abstract
Cleavage and polyadenylation specificity factor (CPSF) plays a key role in pre-mRNA 3'-end formation, recognising the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition [ 1 ].
This entry represents the 100-kilodalton subunit (subunit 2) [ 2 ]. In Xenopus laevis this subunit seems to be predominantly involved in cytoplasmic polyadenylation reaction [ 3 ].
1. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. EMBO J. 23, 616-26
2. Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit. Mol. Cell. Biol. 14, 8183-90
3. The cleavage and polyadenylation specificity factor in Xenopus laevis oocytes is a cytoplasmic factor involved in regulated polyadenylation. Mol. Cell. Biol. 19, 5707-17