InterPro domain: IPR012000

General Information

  • Identifier IPR012000
  • Description Thiamine pyrophosphate enzyme, central domain
  • Number of genes 721
  • Gene duplication stats Loading...
  • Associated GO terms GO:0000287   GO:0030976  

Abstract

A number of enzymes require thiamine pyrophosphate (TPP) (vitamin B1) as a cofactor. It has been shown [ 1 ] that some of these enzymes are structurally related. This central domain of TPP enzymes contains a 2-fold Rossman fold.


1. Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution. J. Mol. Biol. 256, 590-600

Species distribution

Gene table