InterPro domain: IPR041175

This entry represents a domain found in proteins belonging to the VLRF1 clade of the archaeo-eukaryotic RF1 (aeRF1) superfamily. The yeast Vms1 is the founding member the VLRF1 (Vms1-Like Release Factor-1) clade. In addition to the eukaryotic orthologs of Vms1 the VLRF1 clade also contains members from certain bacteria, predominantly bacteroidetes and more divergent versions in certain Archaea [ 1 ].

Proteins containing this domain have a conserved glutamine residue in the release factor catalytic loop, suggesting they function as active peptidyl-tRNA hydrolases at the ribosome [ 2 ].

1. Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes. Nature 557, 446-451