InterPro domain: IPR039853

Pinin (also known as memA and nuclear protein SDK3) is localised at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque [ 1 ]. It is also a transcriptional activator, binding to the the E-box 1 core sequence of the E-cadherin promoter gene [ 2 ]. Pinin is also found in nuclear 'speckles' where it is also an auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs [ 3 ], and a component of the PSAP complex [ 4 ].

1. Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex. J. Cell Biol. 135, 1027-42
2. Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. Mol. Cell. Biol. 24, 10223-35
3. Modulation of alternative pre-mRNA splicing in vivo by pinin. Biochem. Biophys. Res. Commun. 294, 448-55
4. The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. Nat. Struct. Mol. Biol. 19, 378-86