Module
- Number
- 54
- Regulatory Genes
- 7
- Module Genes
- 26
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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srg-14 | F26B1.6 | WBGene00005171 | 297 | View | |
nhr-209 | R07B7.16 | WBGene00011100 | 237 | View | |
nhr-172 | C54F6.9 | WBGene00016927 | 203 | View | |
rga-4 | Y75B7AL.4 | WBGene00022286 | 167 |
rga-4 encodes a GTPase-activating protein (GAP); RNAi experiments predicted to target rga-4 and the related rga-3 gene result in early embryonic defects, specifically defects in cortical contractility, non-muscle myosin NMY-2 distribution, and the relative size of PAR protein domains; in vitro, RGA-4 positively regulates RHO-1 GTPase activity, consistent with genetic studies showing that the rga-3/4(RNAi) phenotype requires RHO-1 activity.
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nhr-122 | Y41D4B.9 | WBGene00003712 | 135 | View | |
F55B11.4 | F55B11.4 | WBGene00010086 | 133 | View | |
nhr-190 | F48G7.11 | WBGene00018622 | 114 | View |
CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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alh-1 | F54D8.3 | WBGene00000107 |
alh-1 is orthologous to the human gene ALDEHYDE DEHYDROGENASE 2, MITOCHONDRIAL (ALDH2; OMIM:100650), in which a polymorphism can lead to acute ethanol intolerance.
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C32F10.8 | C32F10.8 | WBGene00016333 | View | |
C36A4.9 | C36A4.9 | WBGene00007969 | View | |
cri-3 | F59A2.3 | WBGene00010303 | View | |
elo-1 | F56H11.4 | WBGene00001239 |
elo-1 encodes a component of C-18 polyunsaturated fatty acid (PUFA) elongase that is required for normal elongation of n-6 and n-3 20-carbon PUFA in vivo; ELO-1 is a condensing enzyme that elongates n-6 and n-7 (and, with less efficiency, n-3) series C18 PUFAs.
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F22F7.1 | F22F7.1 | WBGene00017719 | View | |
F59C6.5 | F59C6.5 | WBGene00010326 | View | |
fbp-1 | K07A3.1 | WBGene00001404 |
fbp-1 encodes fructose 1,6-bisphosphatase, a gluconeogenic enzyme that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate in a reaction that reverses the third enzymatic step of glycolysis; in C. elegans, loss of fbp-1 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities; FBP-1 is orthologous to human FBP1 (OMIM:229700, mutated in FBP deficiency).
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gst-1 | R107.7 | WBGene00001749 |
gst-1 encodes a putative glutathione S-transferase of the pi class; GST-1 is required for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; gst-1(RNAi) hermaphrodites are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them.
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hsp-4 | F43E2.8 | WBGene00002008 |
hsp-4 encodes a predicted homolog of the mammalian ER chaperone BiP that affects embryonic and larval viability; expression is most prominent in the spermatheca and transcription of hsp-4 is induced in the gut and in the hypodermis upon ER stress.
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irs-1 | R11A8.6 | WBGene00002152 |
irs-1 encodes a predicted cytoplasmic isoleucyl-tRNA synthetase (IleRS), an aminoacyl-tRNA synthetase that catalyzes the attachment of isoleucine to its cognate tRNA and is thus required for protein biosynthesis; loss of irs-1 activity via RNA-mediated interference (RNAi) results in sterility, embryonic lethality, and slower rates of growth, indicating that IRS-1 is essential for development.
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K07H8.3 | K07H8.3 | WBGene00019505 | View | |
kat-1 | T02G5.8 | WBGene00002183 |
kat-1 encodes a homolog of the human gene ACAT1, which when mutated leads to alpha-methylacetoaceticaciduria (OMIM:203750).
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krs-1 | T02G5.9 | WBGene00002238 | View | |
let-754 | C29E4.8 | WBGene00002879 |
let-754 was identified in screens for ethyl methane sulfonate-induced lethal mutations on chromosome III; the let-754 mutation results in mid larval lethality; the molecular identity of let-754 is not yet known.
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pas-4 | C36B1.4 | WBGene00003925 |
pas-4 encodes a proteasome alpha-type seven subunit of the core 20S proteasome subcomplex; loss of pas-4 activity via RNAi results in a wide variety of defects including embryonic and larval lethality, sterility, abnormal locomotion, slow growth, and abnormal transgene expression and subcellular localization; loss of pas-4 activity also results in activation of SKN-1, a transcription factor required in adult worms for the acute response to oxidative stress and maternally for embryonic development.
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phb-2 | T24H7.1 | WBGene00004015 |
phb-2 encodes one of two subunits of the mitochondrial prohibitin complex; loss of phb-2 activity via RNAi indicates that phb-2 function is required for mitochondrial biogenesis and maintenance and for embryonic, germline, and somatic gonad development.
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ret-1 | W06A7.3 | WBGene00004336 | View | |
trap-1 | Y71F9AM.6 | WBGene00022122 | View | |
unc-60 | C38C3.5 | WBGene00006794 |
unc-60 encodes orthologs of actin depolymerizing factor/cofilin, actin-binding proteins that regulate actin filament dynamics; one UNC-60 isoform, UNC-60A, primarily binds G-actin, depolymerizes actin filaments, and inhibits actin polymerization; UNC-60A is essential during early embryonic development for polar body extrusion, cytokinesis, and embryonic patterning; UNC-60B, which does not inhibit actin polymerization, binds F- and G-actin and influences the rate of actin polymerization by the UNC-60B:actin ratio; UNC-60B is required for actin filament organization in body wall muscle, locomotion, and for efficient actin filament disassembly by UNC-78, an actin interactin protein 1 (AIP1) ortholog; UNC-60A and UNC-60B are differentially expressed: UNC-60A is found in oocytes, embryos, and the adult gonad and intestine, while UNC-60B is found in body wall muscle, the vulva, and spermatheca.
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vha-8 | C17H12.14 | WBGene00006917 |
vha-8 encodes an ortholog of subunit E of the cytoplasmic (V1) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-8 is a predicted cytosolic stator (stalk) component; VHA-8 is required for embryonic and larval viability, for ovulation, and for receptor-mediated endocytosis of yolk protein; VHA-8 is highly expressed in the cytoplasm of excretory canals throughout development, and in the stacked apical plasma membrane sheets of syncytial hypodermal cells; general levels of VHA-8 protein are very low in embryos but increase strongly after hatching; vha-8 mutants show necrotic cell death in hypodermis and intestine, paralleling the role of VHA-12 and other V-ATPase subunits in neuronal necrosis; VHA-8 is dispensable for alae formation, like the V1 subunit VHA-13, but not like the V0 subunits VHA-1 and VHA-4.
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W07G4.4 | W07G4.4 | WBGene00012338 | View | |
W08E12.7 | W08E12.7 | WBGene00021088 | View | |
Y22D7AL.10 | Y22D7AL.10 | WBGene00021248 | View | |
Y57G11C.15 | Y57G11C.15 | WBGene00013311 | View | |
ZC395.10 | ZC395.10 | WBGene00022599 | View |