Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

vha-8  

Sequence Name

C17H12.14  

WB ID

WBGene00006917  

Description

vha-8 encodes an ortholog of subunit E of the cytoplasmic (V1) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-8 is a predicted cytosolic stator (stalk) component; VHA-8 is required for embryonic and larval viability, for ovulation, and for receptor-mediated endocytosis of yolk protein; VHA-8 is highly expressed in the cytoplasm of excretory canals throughout development, and in the stacked apical plasma membrane sheets of syncytial hypodermal cells; general levels of VHA-8 protein are very low in embryos but increase strongly after hatching; vha-8 mutants show necrotic cell death in hypodermis and intestine, paralleling the role of VHA-12 and other V-ATPase subunits in neuronal necrosis; VHA-8 is dispensable for alae formation, like the V1 subunit VHA-13, but not like the V0 subunits VHA-1 and VHA-4.