Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

pas-4  

Sequence Name

C36B1.4  

WB ID

WBGene00003925  

Description

pas-4 encodes a proteasome alpha-type seven subunit of the core 20S proteasome subcomplex; loss of pas-4 activity via RNAi results in a wide variety of defects including embryonic and larval lethality, sterility, abnormal locomotion, slow growth, and abnormal transgene expression and subcellular localization; loss of pas-4 activity also results in activation of SKN-1, a transcription factor required in adult worms for the acute response to oxidative stress and maternally for embryonic development.