Gene: AT2G27120

General Information

Computational description TILTED 2 (TIL2); FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, zinc ion binding, nucleic acid binding; INVOLVED IN: DNA replication; EXPRESSED IN: leaf whorl, sperm cell, male gametophyte, flower, pollen tube; EXPRESSED DURING: M germinated pollen stage, 4 anthesis; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), Domain of unknown function DUF1744 (InterPro:IPR013697), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134); BEST Arabidopsis thaliana protein match is: DNA polymerase epsilon catalytic subunit (TAIR:AT1G08260.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0006260	IEA	GOA Database	DNA replication
GO:0006260	IEA	InterPro	DNA replication
GO:0006281	IEA	Gene Ontology	DNA repair
GO:0006281	IEA	InterPro	DNA repair
GO:0000278	IBA	Gene Ontology	mitotic cell cycle	1
GO:0006297	IBA	Gene Ontology	nucleotide-excision repair, DNA gap filling	1
GO:0006287	IBA	Gene Ontology	base-excision repair, gap-filling	1
GO:0045004	IBA	Gene Ontology	DNA replication proofreading	1
GO:0006272	IBA	Gene Ontology	leading strand elongation	1
GO:0090305	IEA	GOA Database	nucleic acid phosphodiester bond hydrolysis
GO:0071897	IEA	GOA Database	DNA biosynthetic process

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0003887	IBA IEA	Gene Ontology	DNA-directed DNA polymerase activity	1
GO:0003887	IEA	InterPro	DNA-directed DNA polymerase activity
GO:0051539	IEA	GOA Database	4 iron, 4 sulfur cluster binding
GO:0051536	IEA	GOA Database	iron-sulfur cluster binding
GO:0046872	IEA	GOA Database	metal ion binding
GO:0003677	IEA	GOA Database	DNA binding
GO:0003677	IBA	Gene Ontology	DNA binding	1
GO:0003677	IEA	InterPro	DNA binding
GO:0016779	IEA	GOA Database	nucleotidyltransferase activity
GO:0016740	IEA	GOA Database	transferase activity
GO:0003676	IEA	GOA Database	nucleic acid binding
GO:0003676	IEA	InterPro	nucleic acid binding
GO:0008270	IEA	Gene Ontology	zinc ion binding
GO:0008270	IEA	InterPro	zinc ion binding
GO:0000166	IEA	Gene Ontology	nucleotide binding
GO:0000166	IEA	InterPro	nucleotide binding
GO:0008310	IBA	Gene Ontology	single-stranded DNA 3'-5' exodeoxyribonuclease activity	1

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0005634	IEA	GOA Database	nucleus
GO:0005634	ISM	Gene Ontology	nucleus
GO:0005634	IEA	InterPro	nucleus
GO:0008622	IPI ISS IEA	Gene Ontology	epsilon DNA polymerase complex	2
GO:0008622	IEA	InterPro	epsilon DNA polymerase complex

Experimental Evidence

Computational Reviewed Evidence

Electronic Evidence

InterPro	Description
IPR043502	DNA/RNA polymerase superfamily
IPR013697	DNA polymerase epsilon, catalytic subunit A, C-terminal
IPR042087	DNA polymerase family B, thumb domain
IPR006133	DNA-directed DNA polymerase, family B, exonuclease domain
IPR036397	Ribonuclease H superfamily
IPR029703	DNA polymerase epsilon catalytic subunit
IPR012337	Ribonuclease H-like superfamily
IPR006134	DNA-directed DNA polymerase, family B, multifunctional domain
IPR023211	DNA polymerase, palm domain superfamily
IPR006172	DNA-directed DNA polymerase, family B

Mapman id	Description
13.2.3.3.1	Cell cycle organisation.DNA replication.elongation.DNA polymerase epsilon complex.catalytic component POL2/POLE1