InterPro domain: IPR036397
General Information
- Identifier IPR036397
- Description Ribonuclease H superfamily
- Number of genes 39072
- Gene duplication stats Loading...
- Associated GO terms GO:0003676
Abstract
The catalytic domain of several polynucleotidyl transferases share a similar structure, consisting of a 3-layer alpha/beta/alpha fold that contains mixed beta sheets, suggesting that they share a similar mechanism of catalysis. Polynucleotidyl transferases containing this domain include ribonuclease H class I (RNase HI) and class II (RNase HII), HIV RNase (reverse transcriptase domain), retroviral integrase (catalytic domain), Mu transposase (core domain), transposase inhibitor Tn5 (containing additional all-alpha subdomains), DnaQ-like 3'-5' exonucleases (exonuclease domains), RuvC resolvase, and mitochondrial resolvase ydc2 (catalytic domain) [ 1 , 2 , 3 ].
1. Crystallographic analyses of an active HIV-1 ribonuclease H domain show structural features that distinguish it from the inactive form. Acta Crystallogr. D Biol. Crystallogr. 49, 423-7
2. Retroviral integrases and their cousins. Curr. Opin. Struct. Biol. 6, 76-83
3. Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance. Eur. J. Biochem. 270, 2837-47