InterPro domain: IPR043502

This entry represents the DNA/RNA polymerase superfamily, which includes DNA polymerase I, reverse transcriptase, T7 RNA polymerase, lesion bypass DNA polymerase (Y-family), RNA-dependent RNA-polymerase and dsRNA phage RNA-dependent RNA-polymerase. These enzymes share a similar protein fold at their active site, which resembles the palm subdomain of the right-hand-shaped polymerases [ 1 ].

1. Common Structural Core of Three-Dozen Residues Reveals Intersuperfamily Relationships. Mol. Biol. Evol. 33, 1697-710