Gene: AT1G08260

General Information

tid AT1G08260.1
symbol TIL1
Alias ABO4,ABA OVERLY SENSITIVE 4,EMB142,EMBRYO DEFECTIVE 142,EMB2284,EMBRYO DEFECTIVE 2284,EMB529,EMBRYO DEFECTIVE 529,ESD7,EARLY IN SHORT DAYS 7,POL2A
full_name TILTED 1
uniprot F4HW04

Computational description TILTED 1 (TIL1); FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, zinc ion binding, nucleic acid binding; INVOLVED IN: positive regulation of S phase of mitotic cell cycle, negative regulation of long-day photoperiodism, flowering, embryo development ending in seed dormancy; LOCATED IN: apoplast, epsilon DNA polymerase complex; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), Domain of unknown function DUF1744 (InterPro:IPR013697), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134); BEST Arabidopsis thaliana protein match is: DNA polymerase epsilon catalytic subunit (TAIR:AT2G27120.1); Has 2011 Blast hits to 1700 proteins in 652 species: Archae - 331; Bacteria - 603; Metazoa - 305; Fungi - 291; Plants - 83; Viruses - 58; Other Eukaryotes - 340 (source: NCBI BLink).

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0006260	IEA	GOA Database	DNA replication
GO:0006260	IEA	InterPro	DNA replication
GO:0071897	IEA	GOA Database	DNA biosynthetic process
GO:0006281	IEA	GOA Database	DNA repair
GO:0006281	IEA	InterPro	DNA repair
GO:0048579	IMP	Gene Ontology	negative regulation of long-day photoperiodism, flowering	1
GO:0009793	IMP NAS	Gene Ontology	embryo development ending in seed dormancy
GO:0010086	IMP	Gene Ontology	embryonic root morphogenesis	2
GO:0051302	IMP	Gene Ontology	regulation of cell division	2
GO:0006287	IBA	Gene Ontology	base-excision repair, gap-filling	3
GO:0006297	IBA	Gene Ontology	nucleotide-excision repair, DNA gap filling	3
GO:0045004	IBA	Gene Ontology	DNA replication proofreading	3
GO:0006272	IBA	Gene Ontology	leading strand elongation	3
GO:0000278	IBA	Gene Ontology	mitotic cell cycle	3
GO:0090305	IEA	GOA Database	nucleic acid phosphodiester bond hydrolysis

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0003676	IEA	GOA Database	nucleic acid binding
GO:0003676	IEA	InterPro	nucleic acid binding
GO:0003887	IEA	GOA Database	DNA-directed DNA polymerase activity
GO:0003887	IBA	Gene Ontology	DNA-directed DNA polymerase activity	3
GO:0003887	IEA	InterPro	DNA-directed DNA polymerase activity
GO:0051539	IEA	GOA Database	4 iron, 4 sulfur cluster binding
GO:0051536	IEA	GOA Database	iron-sulfur cluster binding
GO:0046872	IEA	GOA Database	metal ion binding
GO:0003677	IEA	GOA Database	DNA binding
GO:0003677	IBA	Gene Ontology	DNA binding	3
GO:0003677	IEA	InterPro	DNA binding
GO:0016779	IEA	GOA Database	nucleotidyltransferase activity
GO:0016740	IEA	GOA Database	transferase activity
GO:0008270	IEA	Gene Ontology	zinc ion binding
GO:0008270	IEA	InterPro	zinc ion binding
GO:0000166	IEA	Gene Ontology	nucleotide binding
GO:0000166	IEA	InterPro	nucleotide binding
GO:0005515	IPI	Gene Ontology	protein binding	4
GO:0008310	IBA	Gene Ontology	single-stranded DNA 3'-5' exodeoxyribonuclease activity	3

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0005634	IEA	GOA Database	nucleus
GO:0005634	ISM	Gene Ontology	nucleus
GO:0005634	IEA	InterPro	nucleus
GO:0048046	IDA	GOA Database	apoplast
GO:0048046	HDA	Gene Ontology	apoplast	5
GO:0008622	IEA	GOA Database	epsilon DNA polymerase complex
GO:0008622	IDA, IPI IBA	Gene Ontology	epsilon DNA polymerase complex	3 4
GO:0008622	IEA	InterPro	epsilon DNA polymerase complex

Experimental Evidence

Computational Reviewed Evidence

Electronic Evidence

InterPro	Description
IPR013697	DNA polymerase epsilon, catalytic subunit A, C-terminal
IPR043502	DNA/RNA polymerase superfamily
IPR006172	DNA-directed DNA polymerase, family B
IPR042087	DNA polymerase family B, thumb domain
IPR006134	DNA-directed DNA polymerase, family B, multifunctional domain
IPR029703	DNA polymerase epsilon catalytic subunit
IPR012337	Ribonuclease H-like superfamily
IPR006133	DNA-directed DNA polymerase, family B, exonuclease domain
IPR023211	DNA polymerase, palm domain superfamily
IPR036397	Ribonuclease H superfamily

Mapman id	Description
13.2.3.3.1	Cell cycle organisation.DNA replication.elongation.DNA polymerase epsilon complex.catalytic component POL2/POLE1