Module
- Number
- 9
- Regulatory Genes
- 2
- Module Genes
- 57
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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rab-3 | C18A3.6 | WBGene00004267 | 1095 |
rab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons.
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sem-4 | F15C11.1 | WBGene00004773 | 210 |
sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F.
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CLR Predictions
75 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0416.1 | B0416.1 | WBGene00015177 | View | |
C05D10.4 | C05D10.4 | WBGene00015480 | View | |
C07A12.2 | C07A12.2 | WBGene00015560 | View | |
C24G6.2 | C24G6.2 | WBGene00016059 | View | |
C34C6.3 | C34C6.3 | WBGene00007916 | View | |
C38C3.4 | C38C3.4 | WBGene00016513 | View | |
C47D2.1 | C47D2.1 | WBGene00016738 | View | |
C54E4.4 | C54E4.4 | WBGene00016919 | View | |
cav-2 | C56A3.7 | WBGene00000302 |
cav-2 encodes one of two C. elegans proteins related to caveolins, integral transmembrane proteins that are believed to function in regulation of signal transduction and that are the major component of caveolae, specialized lipid rafts found in the plasma membrane of most cell types; as loss of cav-2 function via large-scale RNA-mediated interference (RNAi) screens does not result in any obvious abnormalities, the role of cav-2 in C. elegans development and/or behavior is not yet known; cav-2 mRNA is expressed in eggs and mixed stage populations.
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ceh-18 | ZC64.3 | WBGene00000441 |
ceh-18 encodes a POU-class homeodomain transcription factor; CEH-18 is required in hermaphrodites for specific aspects of gonadal sheath cell differentiation, such as normal cell shape and position, that are essential for negative regulation of oocyte meiotic maturation by the sheath cells; in this process, CEH-18 functions in parallel with the VAB-1/Ephrin receptor as part of a sperm-sensing checkpoint mechanism that prevents oocyte maturation, MAPK activation, and ovulation in the absence of sperm; CEH-18 is expressed in the sheath cell nuclei beginning at the L4 larval stage
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cpx-1 | Y73E7A.4 | WBGene00022271 | View | |
cutl-15 | T21B10.6 | WBGene00011888 | View | |
D2085.7 | D2085.7 | WBGene00008432 | View | |
dur-1 | F25H8.5 | WBGene00001113 |
The dur-1 ('Dauer UpRegulated') gene encodes proteins (DUR-1A and DUR-1C) that are predicted to be hydrophilic and heat-resistant, and that might participate in anhydrobiosis; expression of at least one dur-1 transcript is upregulated in dauer larvae and other transcripts may be specifically expressed in dauer larvae.
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E01G6.2 | E01G6.2 | WBGene00008450 | View | |
egl-13 | T22B7.1 | WBGene00001182 |
egl-13 encodes a SOX domain transcription factor; egl-13 is required for maintenance of the uterine pi cell fate; mutations in egl-13 affect the cell fusion process that makes the vulval-uterine connection and consequently egg laying; egl-13 is expressed in the pi cells, transiently expressed in the rho lineage, in the anchor cell following fusion, and in neurons, body wall muscles, and intestinal cells; egl-13 expression during pi cell fate specification is dually controlled by LAG-1 and FOS-1/JUN-1.
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elp-1 | F38A6.2 | WBGene00001248 |
elp-1 encodes a WD repeat-containing protein that is the sole C. elegans EMAP (echinoderm microtubule-associated protein) homolog; ELP-1 binds microtubules in vitro, but as loss of ELP-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of ELP-1 in C. elegans development and/or behavior is not yet known; ELP-1 is expressed in many tissues, including body wall muscle, male-specific sex muscles, the vulva, spermatheca, sensory neurons, and intestinal cells.
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F31C3.6 | F31C3.6 | WBGene00009288 | View | |
F41C3.8 | F41C3.8 | WBGene00018274 | View | |
F47G6.2 | F47G6.2 | WBGene00018579 | View | |
F48C5.1 | F48C5.1 | WBGene00009842 | View | |
F54D5.15 | F54D5.15 | WBGene00010057 | View | |
flr-4 | F09B12.6 | WBGene00001468 |
flr-4 encodes a predicted Ser/Thr protein kinase that affects sensitivity to fluoride ion, growth, defecation cycle periods, dauer formation; expressed in the intestine, the AUA neurons, the pharyngeal isthmus, and in the excretory canal in larval stages.
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gly-6 | H38K22.5 | WBGene00001631 | View | |
H10D18.5 | H10D18.5 | WBGene00019180 | View | |
hot-6 | C13G3.2 | WBGene00001991 | View | |
K03B4.4 | K03B4.4 | WBGene00019355 | View | |
klp-3 | T09A5.2 | WBGene00002216 |
klp-3 encodes a C-terminal kinesin motor protein orthologous to Drosophila NCD and Saccharomyces cerevisiae KAR3; expression of antisense klp-3 RNA under the control of a heat shock promoter suggests that KLP-3 plays a role in chromosome movement and segregation that is essential for germline and embryonic development; klp-3 mRNA is expressed at a low level in mixed-stage RNA preparations; consistent with this, a klp-3::lacZ fusion is expressed in newly hatched larvae in the specialized epithelial marginal cells in the pharynx and muscle cells in the posterior gut region.
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lin-11 | ZC247.3 | WBGene00003000 |
lin-11 encodes a predicted LIM homeodomain transcription factor that affects vulval development, neuronal development and fate specification, utse cell differentiation, and fertility; it is expressed in some neurons, the vulva, pi cells and their progeny, and the spermatheca.
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M02F4.3 | M02F4.3 | WBGene00019737 |
M02F4.3 encodes a predicted transmembrane protein orthologous to human ACDP1-ACDP4 and S. cerevisiae MAM3, and paralogous to C01H6.6, C33D12.2, C52D10.12, R04E5.2, and R13G10.4; by orthology with MAM3, M02F4.3 may participate in metal homoeostasis; M02F4.3, MAM3, and ACDP1-ACDP4 belong to a family of proteins (sharing an ACD domain) from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein; bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; M02F4.3 has no obvious function in RNAi assays.
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nac-3 | K08E5.2 | WBGene00003519 |
nac-3 encodes a high affinity, sodium-coupled dicarboxylate transporter that is one of four C. elegans proteins related to Drosophila Indy and the mammalian NaDC1 and NaDC3 transporters; when expressed in a heterologous system, NAC-3 exhibits high affinity sodium/succinate cotransporter activity indicating that, functionally, NAC-3 is more closely related to mammalian NaDC3 than NaDC1; nac-3 mRNA is present during larval and adult stages, with highest levels seen in L3 and L4 larvae; nac-3::gfp reporter fusions are expressed in the intestine, from early larval stages through adulthood; the effects of nac-3(RNAi) on average lifespan are variable, with reports of no effect on lifespan and reports of a 15% increase in lifespan in affected animals.
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nhr-50 | C06C6.5 | WBGene00003640 | View | |
nmgp-1 | F13H8.4 | WBGene00017437 |
F13H8.4 encodes a homolog of the human neuronal membrane glycoproteins PLP1 (OMIM:300401, mutated in Pelizaeus-Merzbacher disease and spastic paraplegia), M6A (OMIM:601275), and M6B (300051); the presence of a myelin-related protein in C. elegans is currently unexplained, but suggests that some evolutionary precursor of myelin may exist in invertebrates, perhaps involving septate junctions between cells.
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opt-3 | F56F4.5 | WBGene00003878 |
opt-3 encodes a H+-coupled oligopeptide transporter; when expressed in Xenopus oocytes and mammalian cells, OPT-3 can function in H+-coupled dipeptide transport, but in Xenopus oocytes, OPT-3 appears to function predominantly as a H+ channel; an opt-3::gfp promoter fusion is reportedly expressed in neurons and in the pharynx.
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pdfr-1 | C13B9.4 | WBGene00015735 |
pdfr-1 encodes, by alternative splicing, three isoforms of a G-protein-coupled receptor (GPCR) required for normal locomotion; PDFR-1 is orthologous to Drosophila pigment dispersing factor (PDF) receptors, and to human CALCR (OMIM:114131, associated with susceptibility to osteoporesis); pdfr-1 is expressed in all body wall muscles and many head and tail neurons; the C. elegans neuropeptides PDF-1a, PDF-1b, or PDF-2 (orthologous to Drosophila PDF) activated PDFR-1 receptors with dose-dependent nanomolar potency; in vivo, excess PDF-2 induces a movement phenotype like that seen in a pdf-1 null mutant, indicating that PDF-1a/b and PDF-2 exert opposite effects on PDFR-1.
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plc-1 | F31B12.1 | WBGene00004036 |
plc-1 encodes a predicted phospholipase C that affects fertility and possesses two functional domains not commonly seen in other phospholipases: a C-terminal Ras-associating domain with structural similarity to RalGDS and AF-6, and an N-terminal CDC25-like domain that possesses structural homology to guanine nucleotide exchange proteins for Ras.
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ptb-1 | D2089.4 | WBGene00004207 | View | |
ptp-1 | C48D5.2 | WBGene00004213 |
ptp-1 encodes a non-receptor tyrosine phosphatase containing Band 4.1 and PDZ domains that may function in linking cytoplasmic proteins and signaling molecules to sites on the plasma membrane; by homology, PTP-1 is predicted to function in cell signaling, but as loss of PTP-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of PTP-1 in C. elegans development and/or behavior is not yet known.
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rhgf-2 | T08H4.1 | WBGene00006476 | View | |
rpy-1 | C18H9.7 | WBGene00004507 |
rpy-1 is orthologous to the human gene 43KDA ACETYLCHOLINE RECEPTOR-ASSOCIATED PROTEIN (RAPSN; OMIM:601592), which when mutated leads to congenital myasthenic syndrome.
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ser-4 | Y22D7AR.13 | WBGene00004779 |
ser-4 encodes an ortholog of mammalian 5-HT1 metabotropic serotonin receptors; SER-4 is required for normal inhibition of movement by 5-HT, with ser-4 mutants being hyperactive; SER-4 is partly required for male tail curling, with ser-4 mutants showing reduced curling in exogenous 5-HT; SER-4 is dispensable for the stimulation of egg-laying by 5-HT and by the uptake inhibitor fluoxetine; SER-4 may actually inhibit egg-laying, since egg-laying ser-4 mutants are moderately hypersensitive to 5-HT, and mutant ser-4 hermaphrodites are partly depleted of eggs, suggesting that their egg-laying is weakly constitutive; however, SER-4 is required for stimulation of egg-laying by the tricyclic antidepressant imipramine, suggesting that imipramine drives HSNs to secrete some non-5-HT neurotransmitter which then activates SER-4; SER-4 is expressed in neurons (RIB and RIS, other head, pharyngeal, sublateral, retrovesicular ganglion, PVT, and either DVA or DVC); SER-4 has a low affinity for serotonin (5-HT), and overall pharmacological similarities to mammalian 5-HT1 receptors; SER-4 is probably antagonized by mianserin; heterologously expressed SER-4, when challenged with 5-HT, diminishes intracellular adenylate cyclase activity; LIM-6 is required for normal expression of SER-4 in RIS interneurons.
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sgn-1 | F07H5.2 | WBGene00004790 | View | |
sto-5 | F41G4.3 | WBGene00006067 | View | |
syn-2 | F48F7.2 | WBGene00006372 | View | |
T01D3.7 | T01D3.7 | WBGene00045409 | View | |
T27F2.2 | T27F2.2 | WBGene00012100 |
T27F2.2 encodes a homolog of human SIPA1/EHBP1L1 (OMIM:602180) and its paralogs.
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T28B4.1 | T28B4.1 | WBGene00020884 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
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T28D6.4 | T28D6.4 | WBGene00012124 | View | |
tat-2 | H06H21.10 | WBGene00019166 | View | |
tpa-1 | B0545.1 | WBGene00006599 |
tpa-1 encodes two protein kinase C isoforms, TPA-1A and TPA-1B; analysis of tpa-1 mutations indicates that at least one TPA-1 isoform plays a role in nicotine-induced adaptation and that both isoforms appear to play a role in gpa-12/G protein-mediated signaling that modulates feeding and growth.
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twk-29 | F46A9.3 | WBGene00006681 | View | |
unc-38 | F21F3.5 | WBGene00006774 |
unc-38 encodes a nicotinic acetylcholine receptor (nAChR) alpha subunit; UNC-38 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with ACR-2, ACR-3, UNC-29, and LEV-1, non-alpha nAChR subunits, the resulting multimer can form levamisole-gated channels; UNC-38 is expressed postsynaptically in muscles and neurons where it colocalizes with TAX-6, and with ACR-8, ACR-12, and UNC-29, respectively.
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VM106R.1 | VM106R.1 | WBGene00014848 | View | |
Y41G9A.3 | Y41G9A.3 | WBGene00021527 | View | |
Y75B8A.5 | Y75B8A.5 | WBGene00013542 | View | |
ZK1010.4 | ZK1010.4 | WBGene00014178 | View | |
ZK637.1 | ZK637.1 | WBGene00014021 | View |