Transcription regulatory networks in Caenorhabditis elegans
Gene
- Public Gene Name
-
pdfr-1
- Sequence Name
- C13B9.4
- WB ID
- WBGene00015735
- Description
-
pdfr-1 encodes, by alternative splicing, three isoforms of a G-protein-coupled receptor (GPCR) required for normal locomotion; PDFR-1 is orthologous to Drosophila pigment dispersing factor (PDF) receptors, and to human CALCR (OMIM:114131, associated with susceptibility to osteoporesis); pdfr-1 is expressed in all body wall muscles and many head and tail neurons; the C. elegans neuropeptides PDF-1a, PDF-1b, or PDF-2 (orthologous to Drosophila PDF) activated PDFR-1 receptors with dose-dependent nanomolar potency; in vivo, excess PDF-2 induces a movement phenotype like that seen in a pdf-1 null mutant, indicating that PDF-1a/b and PDF-2 exert opposite effects on PDFR-1.
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