Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

nac-3  

Sequence Name

K08E5.2  

WB ID

WBGene00003519  

Description

nac-3 encodes a high affinity, sodium-coupled dicarboxylate transporter that is one of four C. elegans proteins related to Drosophila Indy and the mammalian NaDC1 and NaDC3 transporters; when expressed in a heterologous system, NAC-3 exhibits high affinity sodium/succinate cotransporter activity indicating that, functionally, NAC-3 is more closely related to mammalian NaDC3 than NaDC1; nac-3 mRNA is present during larval and adult stages, with highest levels seen in L3 and L4 larvae; nac-3::gfp reporter fusions are expressed in the intestine, from early larval stages through adulthood; the effects of nac-3(RNAi) on average lifespan are variable, with reports of no effect on lifespan and reports of a 15% increase in lifespan in affected animals.