Module
- Number
- 189
- Regulatory Genes
- 3
- Module Genes
- 3
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
---|---|---|---|---|---|
gla-3 | T02E1.3 | WBGene00011376 | 730 |
gla-3 encodes a TIS11-like protein with two CCCH-like zinc-finger domains that inhibits apoptosis in the germline, and weakly inhibits RAS signalling in vulval development along with RAS-induced muscle protein degradation; GLA-3 inhibits physiological apoptosis in oocytes, keeping it down to a normal level of ~50% in hermaphrodite gonads; gla-3 is expressed in the germline of L4 larvae and adults, and interacts with mpk-1 both genetically and physically; gla-3 requires core apoptotic proteins (CED-3 and CED-4) for its excess apoptotic mutant phenotype, but not others (CEP-1, CLK-2, or HUS-1) required for DNA damage-induced apoptosis; gla-3 mutants have increased germline apoptosis and reduced brood size due to defective pachytene exit from meiosis I, and also show weak enhancment of the multivulva phenotype of let-60(gf) or lip-1(zh15) mutations; gla-3 mutants have temperature-sensitive progressive muscle dystrophy, consistent with hyperactivation of the RAS/MAPK pathway in muscle cells; gla-3(RNAi) hermaphrodites display elevated levels of physiological germline apoptosis, independent of CEP-1.
|
View |
nhr-15 | F33E11.1 | WBGene00003614 | 249 |
nhr-15 is predicted to encode a member of the nuclear hormone receptor family.
|
View |
cey-2 | F46F11.2 | WBGene00000473 | 215 |
cey-2 encodes a cold-shock/Y-box domain-containing protein; by homology, CEY-2 is predicted to function as either an RNA-binding protein involved in translation or RNA processing, or a DNA-binding protein involved in transcriptional regulation; cey-2 mRNA is expressed maternally in the early embryo, in a pattern characteristic of class II maternal RNAs, which are initially detected throughout the embryo but restricted to the P, or germline, lineage as cell division progresses; CEY-2 associates with CGH-1 and CEY-3/4 in cytoplasmic particles of the gonad and early embryo; as loss of cey-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cey-2 in C. elegans development and/or behavior is not yet known.
|
View |
CLR Predictions
11 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
---|---|---|---|---|
aak-1 | PAR2.3 | WBGene00019801 |
aak-1 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); aak-1 activity is required, in parallel with aak-2 and downstream of daf-2, daf-7, and par-4, for negative regulation of germline proliferation during dauer development.
|
View |
cki-2 | T05A6.2 | WBGene00000517 |
cki-2 encodes a cyclin-dependent kinase (CDK) inhibitor of the CIP/KIP family, orthologous to human CDKN1C (OMIM:600856, which when mutated leads to Beckwith-Wiedemann syndrome) that may play a role in cell cycle progression during embryogenesis; CKI-2 interacts with PCN-1, a proliferating cell nuclear antigen homolog, SMO-1, a SUMO (ubiquitin related) homolog, and the RING domain-containing protein C06A5.9.
|
View |
tpxl-1 | Y39G10AR.12 | WBGene00021470 | View |