Module
- Number
- 14
- Regulatory Genes
- 5
- Module Genes
- 40
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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hmp-2 | K05C4.6 | WBGene00001979 | 356 |
hmp-2 encodes a beta-catenin; HMP-2 activity is required during embryonic development for cell adhesion at adherens junctions, cell migration, and body morphogenesis; as a beta-catenin, HMP-2 likely functions solely as part of a cadherin-catenin complex, as in yeast two-hybrid assays, HMP-2 is the only C. elegans beta-catenin that binds HMP-1/alpha-catenin and HMR-1/cadherin; additionally, in the embryo, HMP-2 co-localizes to sites of epithelial cell contacts with HMP-1 and HMR-1/cadherin; however, despite its normal role in embryonic cell adhesion, HMP-2 can activate transcription and when overexpressed in vivo, can partially rescue vulval defects produced by loss of BAR-1/beta-catenin, suggesting that HMP-2 has retained the ability to interact with the Wnt signaling pathway.
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ztf-18 | T24C4.7 | WBGene00020763 | 343 | View | |
F37B4.10 | F37B4.10 | WBGene00018140 | 246 | View | |
Y43C5A.2 | Y43C5A.2 | WBGene00012782 | 239 | View | |
F53H10.2 | F53H10.2 | WBGene00010012 | 185 | View |
CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0379.1 | B0379.1 | WBGene00007155 | View | |
bcat-1 | K02A4.1 | WBGene00001149 |
bcat-1 encodes a branched-chain amino acid aminotransferase that, by homology, is predicted to catalyze the first reaction in the catabolism of essential branched-chain amino acids such as leucine, isoleucine, and valine; in C. elegans, large-scale RNA-mediated interference (RNAi) screens indicate that bcat-1 activity is required for embryonic and larval development.
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C18B2.5 | C18B2.5 | WBGene00015956 | View | |
C18E9.9 | C18E9.9 | WBGene00007689 | View | |
C29F3.7 | C29F3.7 | WBGene00007807 | View | |
C48E7.1 | C48E7.1 | WBGene00016749 | View | |
cat-4 | F32G8.6 | WBGene00000298 |
cat-4 encodes an ortholog of the human GTP cyclohydrolase I gene (GCH1; OMIM:600225), which when mutated leads to dystonia; CAT-4 is involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration; CAT-4 acts in the same genetic pathway as flp-1.
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clc-1 | C09F12.1 | WBGene00000522 |
clc-1 encodes a claudin homolog, closely similar to CLC-2, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-1 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the pharynx to dyes; clc-1 is expressed in spermatheca, pharynx, intestine, hypodermis, the excretory-secretory system, and the cell-cell junctions of the vulva; in pharyngeal cells, CLC-1 colocalizes with AJM-1 in long thin lines, parallel to the pharyngeal axis and lining the lumenal surface, that appear to correspond with apical intercellular junctions.
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col-65 | K08C9.4 | WBGene00000641 | View | |
cri-2 | K07C11.5 | WBGene00019478 |
K07C11.5 is orthologous to the human gene SIMILAR TO TISSUE INHIBITOR OF METALLOPROTEINASE 3 (SORSBY FUNDUS DYSTROPHY, PSEUDOINFLAMMATORY) (TIMP3; OMIM:188826), which when mutated leads to disease.
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F09B12.3 | F09B12.3 | WBGene00008607 | View | |
F15A4.6 | F15A4.6 | WBGene00008841 | View | |
F20A1.1 | F20A1.1 | WBGene00017613 | View | |
F53A9.1 | F53A9.1 | WBGene00018724 | View | |
F54F11.2 | F54F11.2 | WBGene00010070 |
F54F11.2 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F54F11.2 has no clear orthologs in other organisms.
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F55F3.3 | F55F3.3 | WBGene00010117 | View | |
glt-1 | C12D12.2 | WBGene00001620 |
glt-1 encodes a predicted plasma membrane glutamate transporter that is functional when expressed in Xenopus oocytes; expressed in the M3 pharyngeal neuron, the male tail, some anterior hypodermal cells, and in cells in the terminal bulb of the pharynx.
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grl-4 | F42C5.7 | WBGene00001713 |
grl-4 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-4 is expressed in pharynx, reproductive system, vulva, larval neurons, and larval rectal epithelium; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
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gst-36 | R07B1.4 | WBGene00001784 | View | |
hsp-17 | F52E1.7 | WBGene00002021 |
hsp-17 encodes a heat shock protein that is a member of the hsp16/hsp20/alpha-crystallin family of heat shock proteins; by homology, HSP-17 is predicted to function as a molecular chaperone that protects cells from heat-induced protein aggregation and denaturation; at present, the precise developmental and/or behavioral role of HSP-17, as well as its expression pattern, are not yet known.
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ifa-1 | F38B2.1 | WBGene00002050 |
IFA-1 encodes an essential intermediate filament protein that is coexpressed with the essential IF protein IFB-1; IFA-1 is required for survival past the L1 larva stage, and a normal intestine; IFA-1 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFB-1; IFA-1 is predicted to function as a structural component of the cytoskeleton, and is required for larval development and normal intestinal morphology; ifa-1 is expressed in amphid sensory neurons, in tail neurons and other unidentified neurons, some pharyngeal muscles, the pharyngeal-intestinal valve, the vulva, and the rectum.
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ifc-2 | M6.1 | WBGene00002056 |
ifc-2 encodes three isoforms of an intermediate filament protein dispensable for viability but required for normal movement, growth rate, body size, body shape, and cuticle strength; IFC-2 is present in the cytoplasm of intestinal cells, and at the desmosomes of intestinal and pharyngeal cells.
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K07E1.1 | K07E1.1 | WBGene00019489 | View | |
lec-11 | F38A5.3 | WBGene00002274 |
lec-11 encodes a predicted member of the galectin family that shares highest similarity with lec-7 through lec-10 within the C-terminal tail and also shares a higher relative histidine content in common with lec-7 through lec-10; can bind sugar in vitro.
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lec-4 | C44F1.3 | WBGene00002267 |
lec-4 encodes a predicted galectin that exhibits sugar binding properties in vitro.
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lon-1 | F48E8.1 | WBGene00003055 |
The lon-1 gene encodes a protein belonging to the PR-protein superfamily that is a target of DBL-1 (TGF-beta) signaling, and that regulates polyploidization and body length.
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ncs-2 | F10G8.5 | WBGene00003564 | View | |
nlp-33 | T19C4.7 | WBGene00003771 | View | |
pcp-1 | ZK112.1 | WBGene00003956 |
pcp-1 encodes a predicted prolylcarboxypeptidase (PRCP); by homology, PCP-1 is predicted to function as a lysosomal serine-type peptidase that hydrolyzes proteins containing a penultimate proline residue.
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pfn-2 | F35C8.6 | WBGene00003990 | View | |
pqn-22 | C46G7.4 | WBGene00004112 |
The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
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T13B5.3 | T13B5.3 | WBGene00020471 | View | |
tba-4 | F44F4.11 | WBGene00006530 |
tba-4 encodes a member of the alpha tubulin family that also includes tba-1, tba-2, and tba-3, and affects embryonic viability.
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ttr-5 | C40H1.5 | WBGene00008040 |
C40H1.5 encodes a protein containing a predicted signal sequence followed by a transthyretin-like domain; the product of C40H1.5 belongs to a family of apparently nematode-specific proteins whose function is not yet known.
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W07G4.5 | W07G4.5 | WBGene00012339 | View | |
Y37D8A.16 | Y37D8A.16 | WBGene00012554 | View | |
Y40D12A.2 | Y40D12A.2 | WBGene00021503 | View | |
Y53H1B.2 | Y53H1B.2 | WBGene00013181 | View | |
ZK1058.9 | ZK1058.9 | WBGene00014207 | View | |
ZK593.3 | ZK593.3 | WBGene00014003 | View |