Module
- Number
- 128
- Regulatory Genes
- 2
- Module Genes
- 22
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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hmg-1.2 | F47D12.4 | WBGene00001972 | 725 | View | |
ttll-4 | ZK1128.6 | WBGene00014232 | 276 |
ttll-4 encodes, by alternative splicing, two isoforms of a putative tubulin polyglutamylase orthologous to human TTLL4; TTLL-4 has no obvious function in mass RNAi assays; by orthology, TTLL-4 is expected to initiate glutamyl chains rather than elongating them, to have broad substrate specificity, acting on both alpha- and beta-tubulin, and to have multiple non-tubulin substrates such as nucleosome assembly proteins (NAPs).
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CLR Predictions
14 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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abce-1 | Y39E4B.1 | WBGene00012714 | View | |
B0491.1 | B0491.1 | WBGene00007189 | View | |
B0564.7 | B0564.7 | WBGene00007207 | View | |
C15H11.9 | C15H11.9 | WBGene00007617 | View | |
C37E2.1 | C37E2.1 | WBGene00007993 | View | |
clk-1 | ZC395.2 | WBGene00000536 |
clk-1 encodes the C. elegans ortholog of COQ7/CAT5, a highly conserved demethoxyubiquinone (DMQ) hydroxylase that is necessary for the biosynthesis of ubiquinone (coenzyme Q, Q9) from 5-demethoxyubiquinone (DMQ9); in C. elegans, CLK-1 activity is required for normal physiological rates of growth, development, behavior, and aging, as well as for normal brood sizes.
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clr-1 | F56D1.4 | WBGene00000548 |
A receptor tyrosine phosphatase that negatively regulates the FGF receptorsignaling pathway; it localizes to the plasma membrane.
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D2085.5 | D2085.5 | WBGene00008430 | View | |
dhs-6 | C17G10.8 | WBGene00000970 |
The dhs-6 locus is predicted to encode four transcripts derived from alternative splicing and alternative transcriptional initiation sites; the longest transcript is predicted to encode a member of the eukaryotic translation initiation factor family within its amino-terminal end, and is a member of both the SCP-2 sterol transfer family and short-chain dehydrogenase-reductase families within its carboxyl-terminal end; DHS-6 is predicted to be mitochondrial.
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F20D1.9 | F20D1.9 | WBGene00008979 | View | |
F40F11.2 | F40F11.2 | WBGene00009587 | View | |
ogt-1 | K04G7.3 | WBGene00003858 |
ogt-1 encodes an ortholog of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT; OMIM:300255) with 12 N-terminal tetratricopeptide (TPR) domains (generally thought to enable protein-protein interactions) and a C-terminal putative catalytic domain; although loss of ogt-1 activity has no effect on overall viability or fertility, ogt-1 mutations result in alterations in macronutrient storage and can suppress constitutive dauer formation in daf-2 mutants suggesting that, in C. elegans, ogt-1 may play a regulatory role in nutrient sensing and insulin-like signaling pathways; OGT-1 is expressed in embryos, where it exhibits nuclear and punctate perinuclear localization.
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R05D3.2 | R05D3.2 | WBGene00019877 |
R05D3.2 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:16889) (C7orf2; OMIM:605522), which when mutated leads to disease.
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ril-2 | C14C10.3 | WBGene00007586 | View | |
rsd-3 | C34E11.1 | WBGene00004682 | View | |
T21B10.3 | T21B10.3 | WBGene00011885 | View | |
tag-325 | C38D4.5 | WBGene00008006 | View | |
W07E11.1 | W07E11.1 | WBGene00012326 | View | |
wnk-1 | C46C2.1 | WBGene00006941 |
wnk-1 is orthologous to the human gene PROTEIN KINASE, LYSINE-DEFICIENT 1 (PRKWNK1; OMIM:605232), which when mutated leads to pseudohypoaldosteronism type II.
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xnp-1 | B0041.7 | WBGene00006961 |
xnp-1 encodes an ATP-dependent DNA helicase of the SNF2 family that is orthologous to human XNP/ATR-X, which is associated with a number of X-linked mental retardation syndromes; in C. elegans, xnp-1 activity is required at high temperatures for embryogenesis, somatic gonad development, fertility, and vulval morphogenesis; in addition, animals doubly mutant for xnp-1 and lin-35/Rb, hpl-2/HP1, or nucleosome remodelling and histone deacetylase (NuRD) complex members such as lin-53 and let-418, display larval arrest with growth cessation but continued cell proliferation; xnp-1 is also required, with lin-35/Rb and hpl-2/HP1, for proper regulation of transgene expression; xnp-1 mRNA, detectable in embryos and the germline by in situ hybridization, is expressed at highest levels in embryos with decreasing levels seen in successive larval stages; xnp-1 transcriptional reporter fusions exhibit strong expression beginning at mid-embryogenesis but fading by embryonic morphogenesis; at hatching, expression is observed in all dividing cells including the P lineage, and at later larval stages expression is observed in the vulval precursor cells.
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Y71H2AM.1 | Y71H2AM.1 | WBGene00022166 | View | |
Y73E7A.1 | Y73E7A.1 | WBGene00022268 | View |