Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

ttll-4  

Sequence Name

ZK1128.6  

WB ID

WBGene00014232  

Description

ttll-4 encodes, by alternative splicing, two isoforms of a putative tubulin polyglutamylase orthologous to human TTLL4; TTLL-4 has no obvious function in mass RNAi assays; by orthology, TTLL-4 is expected to initiate glutamyl chains rather than elongating them, to have broad substrate specificity, acting on both alpha- and beta-tubulin, and to have multiple non-tubulin substrates such as nucleosome assembly proteins (NAPs).