Gene
- Public Gene Name
- ogt-1
- Sequence Name
- K04G7.3
- WB ID
- WBGene00003858
- Description
- ogt-1 encodes an ortholog of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT; OMIM:300255) with 12 N-terminal tetratricopeptide (TPR) domains (generally thought to enable protein-protein interactions) and a C-terminal putative catalytic domain; although loss of ogt-1 activity has no effect on overall viability or fertility, ogt-1 mutations result in alterations in macronutrient storage and can suppress constitutive dauer formation in daf-2 mutants suggesting that, in C. elegans, ogt-1 may play a regulatory role in nutrient sensing and insulin-like signaling pathways; OGT-1 is expressed in embryos, where it exhibits nuclear and punctate perinuclear localization.
