InterPro domain: IPR045154
General Information
- Identifier IPR045154
- Description Protein PCF11-like
- Number of genes 371
- Gene duplication stats Loading...
- Associated GO terms GO:0003729 GO:0006369 GO:0000993 GO:0006378 GO:0006379
Abstract
Pcf11 is a subunit and essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination [ 1 , 2 ]. Pcf11 binds to Clp1, another subunit of CFIA whose interaction is responsible for maintaining a tight coupling between the Clp1 nucleotide binding subunit and the other components of the polyadenylation machinery [ 3 , 4 ].
This entry includes Pcf11 and related proteins from animals, fungi and plants.1. Independent functions of yeast Pcf11p in pre-mRNA 3' end processing and in transcription termination. EMBO J. 22, 2167-77
2. Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc. Natl. Acad. Sci. U.S.A. 98, 6080-5
3. Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor. Nucleic Acids Res. 35, 87-99
4. The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site. Nucleic Acids Res. 40, 1214-25