InterPro domain: IPR045152

General Information

  • Identifier IPR045152
  • Description Enhancer of mRNA-decapping protein 4-like
  • Number of genes 347
  • Gene duplication stats Loading...
  • Associated GO terms GO:0031087  

Abstract

Ge-1, also known as EDC4 (enhancer of mRNA-decapping protein 4), is a regulator of mRNA decapping to function in the mRNA P-bodies within the cytoplasm. It has been shown to interact with mTORC1 [ 1 ], coenzyme A synthase [ 2 ] and MARF1 [ 3 ]. It is also involved in the regulation of immune system [ 4 ].

This entry also includes EDC4 homologues from fungi and plants [ 5 ].


1. Crosstalk between Edc4 and mammalian target of rapamycin complex 1 (mTORC1) signaling in mRNA decapping. Int J Mol Sci 15, 23179-95
2. EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase. FEBS Lett 586, 3590-5
3. A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay. Elife 9, e0123223
4. The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6. PLoS One 10, 1549-64
5. Components of the Arabidopsis mRNA decapping complex are required for early seedling development. Plant Cell 19

Species distribution

Gene table