InterPro domain: IPR045148

This entry includes TCRG1/TCRGL from human and related proteins from animals, fungi and plants. TCRG1 (also known as CA150) contains three N-terminal WW domains and six consecutive FF domains. WW and FF domains are versatile modules that mediate protein-protein interactions [ 1 ]. TCRG1 is a transcription elongation factor that interacts with the splicing factor SF1 and with the phosphorylated C-terminal repeat domain (CTD) of RNA polymerase II (RNAPII) through its WW and FF domains, respectively [ 2 ].

This entry also includes Urn1 from budding yeasts and PRP40C from Arabidopsis. They are predicted to be involved in pre-mRNA splicing [ 3 ].

1. Human transcription elongation factor CA150 localizes to splicing factor-rich nuclear speckles and assembles transcription and splicing components into complexes through its amino and carboxyl regions. Mol Cell Biol 26, 4998-5014
2. The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. Mol Cell Biol 21, 7617-28
3. Arabidopsis thaliana PRP40s are RNA polymerase II C-terminal domain-associating proteins. Arch. Biochem. Biophys. 484, 30-8