InterPro domain: IPR045139

Aladin is a WD-repeat protein that regulates Aurora A localization to ensure robust mitotic spindle formation [ 1 ]. Mutations in the Aladin gene cause Achalasia-addisonianism-alacrima syndrome (AAAS), an autosomal recessive disorder characterised by adrenocorticotropic hormone (ACTH)-resistant adrenal failure, achalasia of the esophageal cardia and alacrima [ 2 ].

1. The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation. Mol Biol Cell 26, 3424-38
2. Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene. Hum Mol Genet 10, 283-90