InterPro domain: IPR045088
General Information
- Identifier IPR045088
- Description Aminotransferase ALAT1/2-like
- Number of genes 473
- Gene duplication stats Loading...
- Associated GO terms GO:0008483
Abstract
This entry represents a group of aminotransferases, including ALAT1/2 from humans. ALAT1/2 catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate [ 1 ]. This entry also includes ALAT1/2 found in Arabidopsis mitochondria and GGAT1/2 found in Arabidopsis peroxisomes. GGAT1/2 catalyzes the Glu:glyoxylate aminotransferase (GGT), Ala:glyoxylate aminotransferase (AGT), Ala:2-oxoglutarate aminotransferase (AKT) and Glu:pyruvate aminotransferase (GPT) reactions in peroxisomes [ 2 ].
1. cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase. Genomics 79, 445-50
2. Alanine aminotransferase homologs catalyze the glutamate:glyoxylate aminotransferase reaction in peroxisomes of Arabidopsis. Plant Physiol 131, 215-27