InterPro domain: IPR044812

This family represents a group of plant Lysin motif (LysM) receptor kinases that recognise symbiotic and pathogenic microorganisms in plants, characterised by the presence of one or more lysin motif (LysM) domains in the extracytoplasmic portion [ 1 ]. This entry includes LYK-1 (also known as Chitin elicitor receptor kinase 1, CERK1) and LYK-3 from Arabidopsis. They are cell surface receptors for chitin elicitor (chitooligosaccharides) signalling leading to innate immunity in response to biotic and abiotic stresses. They are involved in the resistance to pathogenic fungi by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP) [ 2 , 3 , 4 ]. These proteins also recognise peptidoglycans and play an important role restricting bacterial growth [ 5 , 5 , 6 ].

1. The Arabidopsis LYSIN MOTIF-CONTAINING RECEPTOR-LIKE KINASE3 regulates the cross talk between immunity and abscisic acid responses. Plant Physiol 165, 262-76
2. Two LysM receptor molecules, CEBiP and OsCERK1, cooperatively regulate chitin elicitor signaling in rice. Plant J 64, 204-14
3. Functional characterization of CEBiP and CERK1 homologs in arabidopsis and rice reveals the presence of different chitin receptor systems in plants. Plant Cell Physiol 53, 1696-706
4. Targeted gene disruption of OsCERK1 reveals its indispensable role in chitin perception and involvement in the peptidoglycan response and immunity in rice. Mol Plant Microbe Interact 27, 975-82
5. Interaction of Medicago truncatula lysin motif receptor-like kinases, NFP and LYK3, produced in Nicotiana benthamiana induces defence-like responses. PLoS One 8, e65055
6. Arabidopsis lysin-motif proteins LYM1 LYM3 CERK1 mediate bacterial peptidoglycan sensing and immunity to bacterial infection. Proc Natl Acad Sci U S A 108, 19824-9