InterPro domain: IPR044716

This entry includes a group of transcriptional corepressors, including LEUNIG (LUG) and LUH from Arabidopsis. They are similar to the animal and fungal Gro/Tup1-type corepressors [ 1 ]. LUG is a transcription repressor subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development [ 2 ]. LUH has been shown to activate MYC2-directed transcription of JAZ2 and LOX2 via the Mediator complex coactivator and the histone acetyltransferase HAC1 [ 3 ]. Both LUG and LUH contain the N-terminal LUFS domain, which is essential for the direct interaction with its cofactor SEUSS [ 4 ]. LUH and LUG exhibit both redundant and divergent functions in embryonic development, floral homeotic gene regulation, and plant biotic and abiotic stress responses [ 5 ].

This entry also includes related proteins from fungi.

1. LEUNIG_HOMOLOG and LEUNIG perform partially redundant functions during Arabidopsis embryo and floral development. Plant Physiol 147, 672-81
2. LEUNIG regulates AGAMOUS expression in Arabidopsis flowers. Development 121, 975-91
3. LEUNIG_HOMOLOG Mediates MYC2-Dependent Transcriptional Activation in Cooperation with the Coactivators HAC1 and MED25. Plant Cell 31, 2187-2205
4. Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development. Proc. Natl. Acad. Sci. U.S.A. 101, 11494-9