InterPro domain: IPR044552

This entry represents a group of plant GDSL esterases/lipases, including GLIP1-5 and GLL25 from Arabidopsis. GDSL LIPASE-LIKE 1 (GLIP1) modulates systemic immunity through the regulation of ethylene signaling components [ 1 ]. GLIP1 and GLIP3 have been shown to contribute to the plant resistance to Botrytis cinerea [ 2 ]. GLIP2 is involved in the resistance to Erwinia carotovora via the negative regulation of auxin signaling [ 3 ]. GLL25, also known as GOLD36, has lost the conserved active site 'GDSL' motif and has no lipase activity. It is Involved in organisation of the endomembrane system and is required for endoplasmic reticulum morphology and organelle distribution [ 4 ].GDSL-type esterases/lipases are hydrolytic enzymes with multifunctional properties, such as broad substrate specificity, regiospecificity, and stereoselectivity [ 5 ]. They have been identified in microbes and many plants. They have diverse physical functions such as affecting the germination rate and early growth of seedlings subjected to high concentrations of glucose, or being involved in biotic stress responses [ 6 ].

1. GDSL lipase 1 regulates ethylene signaling and ethylene-associated systemic immunity in Arabidopsis. FEBS Lett 588, 1652-8
2. Regulation of GDSL Lipase Gene Expression by the MPK3/MPK6 Cascade and Its Downstream WRKY Transcription Factors in Arabidopsis Immunity. Mol Plant Microbe Interact 32, 673-684
3. Genome-wide analysis of GDSL-type esterases/lipases in Arabidopsis. Plant Mol Biol 95, 181-197
4. ERMO3/MVP1/GOLD36 is involved in a cell type-specific mechanism for maintaining ER morphology in Arabidopsis thaliana. PLoS One 7, e49103
5. Multifunctionality and diversity of GDSL esterase/lipase gene family in rice (Oryza sativa L. japonica) genome: new insights from bioinformatics analysis. BMC Genomics 13, 309