InterPro domain: IPR044285
General Information
- Identifier IPR044285
- Description Periodic tryptophan protein 1
- Number of genes 195
- Gene duplication stats Loading...
- Associated GO terms GO:0006364
Abstract
This family represents the periodic tryptophan protein 1 (PWP1), a chromatin-associated factor that regulates transcription during developmental growth as part of the TORC1 and Myc signaling pathway in response to nutrients. It regulates Pol I-mediated rRNA biogenesis and the epigenetic status of rDNA [ 1 ]. Drosophila melanogaster PWP1, also known as Protein no child left behind (nclb), is required in males for both germline stem cell (GSC) maintenance and early stages of germ cell differentiation of germ cell cysts [ 2 ]. In females it is necessary to regulate germ cell differentiation and egg chamber development [ 3 ].
1. PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression. Dev Cell 43, 240-252.e5
2. no child left behind encodes a novel chromatin factor required for germline stem cell maintenance in males but not females. Development 138, 3357-66