InterPro domain: IPR043926

This domain is found in several ATP binding cassette transporters family G (ABCG).

ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily which uses the hydrolysis of ATP to energise diverse biological import and export systems. ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These regions can be found on the same protein (mostly in eukaryotes and bacterial exporters) or on two different ones (mostly bacterial importers) [ 1 ]. The function of the integral inner-membrane protein is to translocate the substrate across the membrane and seems to play an important role in substrate recognition [ 2 ].

ABC family G is a multidrug ATP-binding cassette transporter expressed in the plasma membranes of several tissues that is involved in endogenous substrates translocation, modifies drug pharmacokinetics and acts as a protector against xenobiotics [ 3 ].

1. Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters. J. Mol. Evol. 48, 22-41
2. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol. 39, 361-98
3. Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature 563, 426-430