InterPro domain: IPR043128

This superfamily comprises domains found in several proteins such as reverse transcriptase [ 1 , 2 ], DNA polymerase IV and several nucleotide cyclases, such as the nucleotide-binding GGDEF domain.

The representative domains have DNA-directed DNA polymerase, RNA-directed RNA polymerase and diguanylate cyclase activities, and are involved in viral replication, signal transduction, nucleotide binding, and hydrolysis of cyclic diguanylate.

1. Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase. Nat Chem 5, 174-81
2. Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors. J. Virol. 84, 7625-33