InterPro domain: IPR042057

Lipoxygenases can be classified as 9- and 13-lipoxygenases, according to the position of oxygen incorporation in linoleic acid and linolenic acid, the most important substrates for LOX catalysis in plants. There are six A. thaliana lipoxygenases identified: AtLOX1-6, among which AtLOX-1 and AtLOX-5 are 9S-lipoxygenases, and AtLOX-2, AtLOX-3, AtLOX-4 and AtLOX-6 are 13S-lipoxygenases [ 1 ].

This is the PLAT/LH2 domain of plant lipoxygenase related proteins. Lipoxygenases are nonheme, nonsulfur iron dioxygenases that act on lipid substrates containing one or more (Z,Z)-1,4-pentadiene moieties. In plants, the immediate products are involved in defense mechanisms against pathogens and may be precursors of metabolic regulators [ 2 , 3 , 4 ]. The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins [ 5 ].

1. Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. Lipids 44, 85-95
2. Plant lipoxygenases. Physiological and molecular features. Plant Physiol. 130, 15-21
3. The lipoxygenase pathway. Annu Rev Plant Biol 53, 275-97
4. Plant and fungal lipoxygenases. Prostaglandins Other Lipid Mediat. 68-69, 313-23
5. The PLAT domain: a new piece in the PKD1 puzzle. Curr. Biol. 9, R588-90