InterPro domain: IPR041373

DNA polymerase and ribonuclease H (RNase H) activities allow reverse transcriptases to convert the single-stranded retroviral RNA genome into double-stranded DNA, which is integrated into the host chromosome during infection [ 1 ]. This domain can also be found in animal retrotransposon-like proteins [ 2 ].

This entry represents an RNase H-like domain found in a group of reverse transcriptases, including those transcribed as part of an enzymatic polyprotein.

1. The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus. Structure 12, 819-29
2. Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. Nat. Genet. 40, 243-8