InterPro domain: IPR040892

This domain is found at the N terminus of the 26S proteasome regulatory subunit RPN1 (also known as 26S proteasome non-ATPase regulatory subunit 2 (PSMD2)) [ 1 ]. The domain is formed by an array of alpha helices [ 2 ].

The 26S proteasome is the major ATP-dependent protease in eukaryotes which plays a key role in intracellular protein degradation [ 3 , 4 ].

1. The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death. Cell Res. 26, 869-85
2. The structure of the 26S proteasome subunit Rpn2 reveals its PC repeat domain as a closed toroid of two concentric α-helical rings. Structure 20, 513-21
3. Dissection of the assembly pathway of the proteasome lid in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 396, 1048-53
4. Structure of the human 26S proteasome at a resolution of 3.9 A. Proc. Natl. Acad. Sci. U.S.A. 113, 7816-21