InterPro domain: IPR040813
General Information
- Identifier IPR040813
- Description Small RNA 2'-O-methyltransferase Hen1, La-motif C-terminal domain
- Number of genes 136
- Gene duplication stats Loading...
Abstract
RNA silencing is a conserved regulatory mechanism in fungi, plants and animals that regulates gene expression and defence against viruses and transgenes. A conserved S-adenosyl-l-methionine-dependent RNA methyltransferase, HUA ENHANCER 1 (HEN1), and its homologues are responsible for 2'-O-methylation on the 3' terminal nucleotide of microRNAs and small interfering RNAs (siRNAs). The 2'-O-methylation protects miRNAs and siRNAs from 3'-end uridylation and 3'-to-5' exonuclease-mediated degradation. This domain lies on the C-terminal region of the La-motif domain found in HEN1 [ 1 ].
1. Structural insights into mechanisms of the small RNA methyltransferase HEN1. Nature 461, 823-7
Species distribution
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