InterPro domain: IPR040047
General Information
- Identifier IPR040047
- Description Syndetin
- Number of genes 172
- Gene duplication stats Loading...
- Associated GO terms GO:1990745 GO:0042147 GO:0032456
Abstract
Syndetin (VPS50) is a component of the endosome-associated recycling protein (EARP) complex. This complex and the Golgi-associated retrograde protein (GARP) complex share four of the five subunits, but EARP contains syndetin in place of the Vps54 subunit of GARP, with the effect that the EARP complex is directed to endosomes rather than the Golgi. EARP in required for membrane-fusion during endocytic recycling of receptors and is described as a tethering complex [ 1 ].
1. EARP is a multisubunit tethering complex involved in endocytic recycling. Nat. Cell Biol. 17, 639-50
Species distribution
Gene table
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