InterPro domain: IPR039894

Archaeal Pus10 is responsible for the synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs [ 1 ]. This entry also includes Pus10 homologues from eukaryotes. Human Pus10 homologue is a modulator of TRAIL-induced cell death and is required for the progression of the apoptotic signal through intrinsic mitochondrial cell death [ 2 , 3 ]. Although eukaryotic Pus10 shares a conserved catalytic domain with archaeal Pus10 genes, their biological roles are not resolved [ 4 ].

1. Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA. RNA 14, 2521-7
2. Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol. Cell 12, 627-37
3. DOBI is cleaved by caspases during TRAIL-induced apoptotic cell death. BMB Rep 42, 511-5
4. Evolution of Eukaryal and Archaeal Pseudouridine Synthase Pus10. J. Mol. Evol. 86, 77-89