InterPro domain: IPR039778

General Information

  • Identifier IPR039778
  • Description Programmed cell death protein 4
  • Number of genes 327
  • Gene duplication stats Loading...
  • Associated GO terms GO:0045892  

Abstract

Programmed cell death protein 4 (PDCD4) binds to eukaryotic initiation factor 4A (eIF4A), inhibits translation initiation, and acts as a tumour suppressor. It contains two C-terminal MA3 domains that bind specifically to the eIF4A N-terminal domain (eIF4A-NTD) [ 1 , 2 , 3 ].

This entry also includes MRF1/2/3/4 from plants. They are involved in target of rapamycin (TOR)-egulated translation control, especially under energy-deficient conditions [ 4 ].


1. PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proc. Natl. Acad. Sci. U.S.A. 105, 3274-9
2. Structural basis for translational inhibition by the tumour suppressor Pdcd4. EMBO J. 28, 274-85
3. Crystal structure of the eIF4A-PDCD4 complex. Proc. Natl. Acad. Sci. U.S.A. 106, 3148-53
4. MRF Family Genes Are Involved in Translation Control, Especially under Energy-Deficient Conditions, and Their Expression and Functions Are Modulated by the TOR Signaling Pathway. Plant Cell 29, 2895-2920

Species distribution

Gene table