InterPro domain: IPR039762

General Information

  • Identifier IPR039762
  • Description Nonsense-mediated mRNA decay protein Nmd2/UPF2
  • Number of genes 172
  • Gene duplication stats Loading...
  • Associated GO terms GO:0000184  

Abstract

This entry includes Nmd2 from yeasts and UPF2 from animals. They are involved in the nonsense-mediated mRNA decay (NMD) pathway [ 1 , 2 ]. In the human UPF complex (composed of UPF1/2/3), UPF2 and UPF3b cooperatively stimulate both ATPase and RNA helicase activities of UPF1 [ 3 ].


1. Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. Mol. Cell. Biol. 17, 1580-94
2. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103, 1121-31
3. NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. Nat. Struct. Mol. Biol. 15, 85-93

Species distribution

Gene table