InterPro domain: IPR039741

This entry includes UDP-sugar phosphorylases such as UDP-N-acetylglucosamine pyrophosphorylase, UDP-N-acetylhexosamine pyrophosphorylase (UAP1) and UDP-N-acetylglucosamine diphosphorylase, all of which catalyse the transfer of an uridylyl group. UAP1 has two catalytic domains, UDP-N-acetylgalactosamine pyrophosphorylase ( 2.7.7.83 ) and UDP-N-acetylglucosamine pyrophosphorylase ( 2.7.7.23 ) [ 1 ]. UDP-N-acetylglucosamine diphosphorylase is required for the biosynthesis of UDP-glucosamine, an essential precursor for glycoprotein and glycolipid synthesis and can utilize UDP-glucosamine or UDP-galactosamine [ 2 ].

1. A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc. J. Biol. Chem. 273, 27055-7
2. N-acetylglucosamine-1-P uridylyltransferase 1 and 2 are required for gametogenesis and embryo development in Arabidopsis thaliana. Plant Cell Physiol. 55, 1977-93