InterPro domain: IPR039726

General Information

  • Identifier IPR039726
  • Description Pre-mRNA-processing factor Prp40
  • Number of genes 334
  • Gene duplication stats Loading...
  • Associated GO terms GO:0045292  

Abstract

This entry represents a group of pre-mRNA-processing proteins, including budding yeast Prp40, and its homologues. Prp40 is required for pre-spliceosome formation, which is the first step of pre-mRNA splicing [ 1 ]. In human, there are two Prp40 homologues, PRP40A and PRP40B. They are also involved in pre-mRNA splicing [ 2 ].


1. The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing. Genetics 166, 53-65
2. Prp40 and early events in splice site definition. Wiley Interdiscip Rev RNA 7, 17-32

Species distribution

Gene table