InterPro domain: IPR039637

General Information

  • Identifier IPR039637
  • Description CCR4-NOT transcription complex subunit 7/8/Pop2
  • Number of genes 1099
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004535   GO:0030014  

Abstract

This entry includes subunits CNOT7 and CNOT8 of the CCR4-NOT complex required for RNA degradation. Both CNO7 and CNOT8 are 3'-5' poly(A) exoribonucleases removing the poly-A tail and have somewhat redundant activities [ 1 ]. This entry also includes CNOT7/8 yeast homologue, Pop2, which is a nuclease subunit of the yeast Ccr4-Not complex [ 2 , 3 ].


1. The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. Mol. Biol. Cell 20, 3840-50
2. The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation. Nucleic Acids Res. 29, 2448-55
3. X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex. EMBO Rep. 4, 1150-5

Species distribution

Gene table