InterPro domain: IPR039617

This entry includes CLAVATA3/ESR (CLE)-related proteins 5, 6, 7, 12, 13 and 53. CLE12 and CLE13 control the nodule numbers by interacting with the SUPER NUMERIC NODULES (SUNN)-dependent auto-regulation of nodulation [ 1 , 2 ].

This entry also includes CLE-4A-1 and CLE-4A-2 from Globodera rostochiensis (Golden nematode worm). They mimics host plant CLE extracellular signal peptides that regulate cell fate [ 3 ].

The CLE proteins share a C-terminal CLE domain with CLV3, a small secreted polypeptide that is active as a ligand and has a function in shoot apical meristem maintenance [ 4 ]. In general, the CLE-related proteins are C-terminally processed to generate an active CLE peptide [ 5 ]. These small secreted peptide hormones then function in a variety of developmental and physiological processes [ 6 , 7 ]. CLV3 and other A-type CLE peptides are involved in the suppression of stem cell development in root and shoot development, in contrast to the B-type CLE peptides, CLE41 and CLE44, in the case of Arabidopsis, which are not [ 8 ].

1. Nodule numbers are governed by interaction between CLE peptides and cytokinin signaling. Plant J. 70, 367-76
2. CLE peptides control Medicago truncatula nodulation locally and systemically. Plant Physiol. 153, 222-37
3. Structural and functional diversity of CLAVATA3/ESR (CLE)-like genes from the potato cyst nematode Globodera rostochiensis. Mol. Plant Microbe Interact. 22, 1128-42
4. The Arabidopsis CLV3-like (CLE) genes are expressed in diverse tissues and encode secreted proteins. Plant Mol. Biol. 51, 415-25
5. Evidence for functional conservation, sufficiency, and proteolytic processing of the CLAVATA3 CLE domain. Plant Physiol. 140, 726-33
6. CLE signaling systems during plant development and nematode infection. Plant Cell Physiol. 53, 1989-99
7. Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new family members, correlate with tandem variations in the conserved CLAVATA3/ESR domain. Plant Physiol. 140, 1331-44
8. Plant CLE peptides from two distinct functional classes synergistically induce division of vascular cells. Proc. Natl. Acad. Sci. U.S.A. 105, 18625-30