InterPro domain: IPR039539

This entry represents proteins with an N-terminal NTF2 (nuclear transport factor 2) domain and a C-terminal RRM (RNA recognition motif) domain. It includes mammalian ATP- and magnesium-dependent helicase Ras GTPase-activating protein-binding proteins 1 and 2 [ 1 ] and UBP3-associated protein Bre5 from yeast, which is a co-factor required for de-ubiquitination [ 2 ]. This entry also includes AtMBD6 from Arabidopsis. AtMBD6 maintains gene silencing in Arabidopsis by interacting with RNA binding proteins [ 3 ].

1. Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. Nucleic Acids Res. 27, 817-21
2. Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23. Nat. Cell Biol. 5, 661-7
3. AtMBD6, a methyl CpG binding domain protein, maintains gene silencing in Arabidopsis by interacting with RNA binding proteins. J. Biosci. 42, 57-68