InterPro domain: IPR039340

TFIIIC-102, also known as general transcription factor 3C polypeptide 3 (GTF3C3), is required for RNA polymerase III-mediated transcription and is a component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters [ 1 ]. GTF3C3 contains several tetratricopeptide repeats.

In Saccharomyces cerevisiae, this protein is known as transcription factor tau 131kDa subunit (Tfc4). It is the TFIIIB-assembling subunit of RNA polymerase III transcription initiation factor complex (TFIIIC) [ 2 ]. In Schizosaccharomyces pombe, this subunit is known as Sfc4 [ 3 ].

1. Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. Mol. Cell. Biol. 19, 4944-52
2. The TFIIIB-assembling subunit of yeast transcription factor TFIIIC has both tetratricopeptide repeats and basic helix-loop-helix motifs. Proc. Natl. Acad. Sci. U.S.A. 90, 4027-31
3. Isolation and cloning of four subunits of a fission yeast TFIIIC complex that includes an ortholog of the human regulatory protein TFIIICbeta. J. Biol. Chem. 275, 31480-7