InterPro domain: IPR039298

General Information

  • Identifier IPR039298
  • Description Acyl-coenzyme A thioesterase 13
  • Number of genes 642
  • Gene duplication stats Loading...
  • Associated GO terms GO:0047617  

Abstract

Acyl-coenzyme A thioesterases hydrolyse acyl-CoA to generate free fatty acid and coenzyme A. Acyl-coenzyme A thioesterase 13 (ACOT13) acts on medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Naturally, it exists as a homotetramer and adopts a hotdog fold [ 1 ]. Homologues are found in eukaryotes and bacteria.


1. The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry 48, 1293-304

Species distribution

Gene table