InterPro domain: IPR039204

This functionally diverse eukaryotic family includes the inner mitochondrial membrane Mg2+ transporters Mfm1p/Lpe10p [ 1 ] and Mrs2p [ 2 ] from Saccharomyces cerevisiae; and human MRS2/MRS2L [ 3 ]. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+ [ 4 ].

1. The mitochondrial inner membrane protein Lpe10p, a homologue of Mrs2p, is essential for magnesium homeostasis and group II intron splicing in yeast. Mol. Gen. Genet. 264, 773-81
2. Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of Mrs2, a magnesium ion transporter from yeast inner mitochondrial membrane. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66, 658-61
3. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. Genomics 72, 158-68
4. A novel family of magnesium transport genes in Arabidopsis. Plant Cell 13, 2761-75