InterPro domain: IPR039058

The Yippee-like (YPEL) family proteins share homology to drosophila Yippee, azinc finger binding protein. YPEL proteins are found in essentiallly all theeukaryotes and hence they must play important roles in the maintenance oflife. Subcellular localization of all YPEL proteins to the centrosomes andthe mitotic apparatus suggest their role in the mitosis-associated function.YPEL proteins contain a Yippee domain, which is a putative zinc-finger-like,metal-binding domain [ 1 , 2 , 3 , 4 ].

1. The Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes. Insect Mol. Biol. 10, 77-86
2. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Gene 340, 31-43
3. MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway. Biochem. Cell Biol. 88, 445-50
4. YPEL1 overexpression in early avian craniofacial mesenchyme causes mandibular dysmorphogenesis by up-regulating apoptosis. Dev. Dyn. 244, 1022-30