InterPro domain: IPR038836
General Information
- Identifier IPR038836
- Description Mediator of RNA polymerase II transcription subunit 16
- Number of genes 165
- Gene duplication stats Loading...
- Associated GO terms GO:0016592 GO:0006355
Abstract
This entry includes mediator of RNA polymerase II transcription subunit 16 (MED16; also known as SENSITIVE TO FREEZING 6 or SFR6) which is known only from plants. It is a component of the Mediator complex, which is required for transcription of almost all RNA polymerase II-dependent genes. Mediator provides an interface for activator and repressor proteins to transmit information from regulatory DNA elements to core promoters [ 1 ]. MED16 is a key component in acclimatization of plants to freezing temperatures [ 2 ].
1. Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit. Mol. Cell 26, 717-29
2. Identification of SFR6, a key component in cold acclimation acting post-translationally on CBF function. Plant J. 58, 97-108