InterPro domain: IPR037898

This family includes NudC (nuclear distribution gene C), NudC-like (NudCL) [ 1 ], NudC-like 2/NudC domain-containing protein 2 (NudCL2/NUDCD2)[ 2 ], NudC domain-containing protein 3, and NudC domain protein BOBBER from plants [ 3 ]. All members of the NudC family share a conserved p23 domain, which possesses chaperone activity both in conjunction with and independently of heat shock protein 90 (Hsp90) [ 4 ]. NudC proteins play multiple roles in cell cycle progression, cell migration, inflammatory response, platelet production, carcinogenesis [ 5 , 6 ].

1. A mammalian NudC-like protein essential for dynein stability and cell viability. Proc. Natl. Acad. Sci. U.S.A. 103, 9039-44
2. NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. Proc. Natl. Acad. Sci. U.S.A. 107, 3499-504
3. Partitioning the apical domain of the Arabidopsis embryo requires the BOBBER1 NudC domain protein. Plant Cell 21, 1957-71
4. Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Mol. Cell 43, 229-41
5. Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation. Acta Neuropathol. 113, 591-9
6. Emerging roles of NudC family: from molecular regulation to clinical implications. Sci China Life Sci 59, 455-62