InterPro domain: IPR037813

The DNA-binding general transcription factor complex TFIID is central to the initiation of DNA-dependent RNA polymerase II transcription. TFIID is the only general transcription initiation factor that bind to the TATA box. The binding of TFIID to the TATA-box is the first step in the formation of a complex able to initiate transcription [ 1 ]. TFIID consists of the TATA binding protein (TBP) and 14 TBP-associated factors (TAFs). One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14 [ 2 ].

Transcription initiation factor TFIID subunit 2 (TAF2) is a component of the general purpose transcription factor complex TFIID [ 3 , 4 ]. This entry includes TAF2 from animals, plants and fungi.

1. The general transcription factors of RNA polymerase II. Genes Dev. 10, 2657-83
2. Identification of two novel TAF subunits of the yeast Saccharomyces cerevisiae TFIID complex. J. Biol. Chem. 275, 13895-900
3. Molecular characterization of Saccharomyces cerevisiae TFIID. Mol. Cell. Biol. 22, 6000-13